Background: Men with cystic fibrosis CF have bilateral absence of the vas deferens causing an obstructive azoospermia that is not amenable to surgical correction. Advances in the field of reproductive medicine allow for the procurement of viable sperm and facilitate fertilization and pregnancy in couples where the man has CF. Objectives: To describe patient anatomy and semen characteristics and to determine the pregnancy rates of couples in whom the male partner has CF and who have undergone microsurgical epididymal sperm aspiration coupled with in vitro technology, specifically intracytoplasmic sperm injection ICSI. Design: Retrospective analysis. Setting: Clinical department of urology and two reproductive medicine units. Patients: Thirteen married men with CF who were referred for infertility.
Cystic fibrosis mutation screening in healthy men with reduced sperm quality
By Editorial Team. Infertility can be a complication for adults with cystic fibrosis. Men and women with cystic fibrosis CF usually produce normal levels of sex hormones such as progesterone, estrogen, and testosterone, and can, therefore, enjoy a normal sex life. However, people with CF often face special challenges when it comes to building a family. Ninety-eight percent of men with CF are infertile.
An obvious consequence of this deep change is the increasing question about fertility in both males and females. Cystic Fibrosis in the Light of New Research. As the life expectancy of cystic fibrosis CF patients continues to increase, and more patients become adults with a chronic disease, researching the impact of this disorder on male and female infertility has become increasingly important. Although most men with CF have significant anatomical abnormalities of the reproductive tract causing infertility, most women with CF have anatomically normal reproductive tracts and up to half of them may be able to conceive spontaneously.
While percent of men with cystic fibrosis are infertile, they can still enjoy normal, healthy sex lives and have biological children with the help of assisted reproductive technology ART. To understand the inner workings of infertility in men with cystic fibrosis, it is helpful to first understand the biology of the male reproductive system. It has three primary parts: the testicles, the epididymis and the vas deferens see Figure 1.